Publications & background
Publications on our programs and background literature on our approach and targets
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Journal of Experimental Medicine
September 2025
Discovery of potent and selective inhibitors of human NLRP3 with a novel mechanism of action
September 2025
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BioRxiv
July 2025
Inhibition of NLRP3 by a CNS-penetrating indazole scaffold
July 2025
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Bioorganic & Medicinal Chemistry Letters
April 2024
The discovery of novel and potent indazole NLRP3 inhibitors enabled by DNA-encoded library screening
April 2024
